|
KMID : 0363320000210020251
|
|
Journal of Korean Oriental Internal Medicine
2000 Volume.21 No. 2 p.251 ~ p.257
|
|
|
Effects of Buthus martensi Karsch on tumor promotion in two-stage carcinogenesis in mice
|
|
Jeong In-Chae
Yoon Cheol-Ho
Jung Ji-Chun
|
|
|
Abstract
|
|
|
|
To clarifiy the activating effects of Buthus martensi Karsch(BMK) on tumor promotion in two-stage carcinogenesis in mice was investigated. In vivo system, BMK was seen to gave an inhibitory activity on TPA-induced mouse ear edema. In addition, the BMK was proved to have antitumor-promoting activity in two-stage mouse skin carcinogenesis induced by DMBA and two-stage mouse lung carcinogenesis induced by 4-NQO as a initiator plus TPA and glycerol as a promoter. Moreover, BMK significantly exhibited an cytolytic effect in HepG2 cells and showed significant antitumor activity against Sarcoma-180 bearing mice by oral administration. These results suggest that BMK could be effective in adjuvant chemotherapy for human cancer.
|
|
|
KEYWORD
|
|
|
Buthus martensi Karsch, two-stage carcinogenesis, initiator, promoter
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|